Preclinical Services
As part of our mission to enable other Life Sciences & Healthcare firms in the Indian and global markets, we offer end-to-end pre-clinical services for the successful development of innovative discoveries and innovations to enhance the existing value of the product. We support the discovery and development of products/compounds for diverse industries including Pharmaceuticals, Biologicals, Agrochemicals, Nutraceuticals/Herbal and Cosmetics.
Our preclinical partner facility is an internationally renowned well equipped centre with global standards. The different screening verticals- cell biology, in vivo pharmacology, DMPK, toxicology, analytical departments cater to end to end screening of efficacy and safety in wide spectrum of therapeutic indications.
Besides these primary preclinical services, we provide customized formulation design, discovery and development based on various technologies. We undertake complete lifecycle management of our client assets to reach the clinical stage quickly and efficiently.
Key Services
- Hit to lead optimization
- Lead to candidate identification
- Efficacy models – in vitro & in vivo
- Safety Assessment (GLP studies)
- IND Enabling Studies
- Drug Repositioning
- Analytical Services
- Formulation development
- Target and mechanistic studies
- DMPK
Therapeutic Areas
Oncology
Immunity
Ageing & Wellness
Congnitive Health
Metabolic Disease
Cardiovascular
Hair biology
Dermatology
Pain
Inflammation
Gut Health
Overall wellness
Women’s health
Respiratory health
Infectious diseases
Energy & stamina
Stress & anxiety
Ophthalmology
Service Portfolio
Formulation Development
- Formulation Development
- Lab/Pilot to Commercial Scale Process Development
- Lab/Pilot batch Manufacturing for study
- Product Characterization
- Shelf-Life Evaluation – Stability Study
- Product Docket Preparation and Technology Transfer
- Support to Commercial Scaleup and Process Validation
In Vivo Pharmacology
- In-Vivo efficacy studies using appropriate animal disease models
- In-vivo biomarker assays such as ELISA, Histology, Immunohistochemistry, RT-PCR, WB etc..
- PK-PD Investigation
- Invasive and Non-invasive pharmacological read outs.
- Validation of various surgical models
- New and rare disease model development
- Dose, route and regime optimization studies
DMPK
- In vitro ADME studies
- Pharmacokinetic studies
- Tissue Distribution studies
- PK-PD studies
- Toxicokinetic studies
- Biomarker studies
- Bioanalysis
Analytical Chemistry
- Herbal Product Characterization
- Dose formulation analysis for preclinical studies
- 5 Batch analysis
- Phys-chem studies
- Residue analysis
Cell Biology
- In vitro cell based efficacy screening using validated models in multiple therapeutic areas
- Comprehensive mechanistic elucidation for various class of test items
- In vitro cytotoxicity assays for organ toxicity
- Stem cells based in vitro studies
- Employment of well-established hallmark end point technologies such as Flow cytometry, ELISA, western blotting, PCR, Microscopy etc.
- Efficacy testing of products for claim substantiation
- Wide-ranging panels of Biomarkers in multiple disease and wellness areas
Toxicology
- Acute & Sub-acute toxicity studies
- Sub-chronic & Chronic toxicity studies
- Developmental & Reproductive Toxicity (DART) Studies
- Neurotoxicity studies
Genetic Toxicology
- AMES Test (Salmonella typhimurium & E.coli)
- In vitro & In vivo Chromosomal Aberration Test
- In vitro & In vivo Micronucleus Test
- In vitro Cell Gene Mutation Test
Accreditations
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